ART BMC
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What is the ART BMC?
- The ART BMC system processes autologous bone marrow concentrate effectively and efficiently at point-of-care.
- The system recovers the greatest percentage of nucleated and progenitor cells
- Functionally closed system to minimize sterile breaks
- Thumbwheel allows for selective deconstruction of fluid stack for personalized fluid products
- Efficient concentration yields ultra-low hematocrit with only 1 spin
- 15-20 minute processing time
- Consistently achieves high yields of platelets and mononuclear cells
- GFC = Growth Factor Concentrate = Concentrated Plasma
- GFC Clot = Fibrin Glue with Proteins & Growth Factors!
Included:
- (1) ART BMC Plus Disposable
- (1) Clot Filter
- (3) 35mL Syringes
- (1) 30mL Vaclok
- (2) F-F luer connectors
- (2) syringe caps
Features
- Fully integrated device to minimize sterile breaks
- Disposable
- Thumbwheel allows for variable processing volume
- Only BMC device on the market with integrated fibers
Benefits
- High progenitor cell recovery (avg 90 %)1
- High platelet recovery (avg 71 %)1
- Eliminates turbulence by keeping buffy coat in the collection zone
What Proteins, Growth Factors, and Molecules are Present in GFC?2
- VEGF5
- New blood vessel growth
- Endothelial cell migration and proliferation
- PDGF5
- New blood vessel growth
- MSC recruitment and proliferation
- Helps form bone
- Increases collagen synthesis
- TGF-Beta5
- MSC proliferation
- Bone matrix deposition
- FGF5
- MSC proliferation
- Wound healing
- Alpha 2-Macroglobulin (A2M)6
- Prevents cartilage degeneration
- IRAP3
- Interleukin-1 receptor antagonist protein
- High levels in bone marrow
- Decreases inflammation
- FIBRINOGEN5
- Critcal for clot formation
| Cell Type | Bone marrow concentrate and growth factor |
| Cell Source | BMA |
| Cell Content / Recovery | 90% progenitor cells (CD34+, CFU-F); 71% platelets1 |
| Protein Concentrate | Yes |
| FDA Status | Class I – Exempt |
1 Karli et al. Autologous Regenerative Therapies: Rapid Concentration of Progenitor Cells, Platelets, and Proteins at the Point-of-Care” TERMIS Annual Meeting. (2015) Boston, MA
2 Monteforte et al. “Autologous Protein Scaffold Isolated from Platelet Poor Plasma in Bone Marrow Concentrate” World Stem Cell Summit. (2016) West Palm Beach, FL.
3 Cassano, Jennifer M., et al. “Bone marrow concentrate and platelet-rich plasma differ in cell distribution and interleukin 1 receptor antagonist protein concentration.” Knee Surgery, Sports Traumatology, Arthroscopy (2016): 1-10.
4 Monteforte et al. “Autologous Protein Scaffold Isolated from Platelet Poor Plasma in Bone Marrow Concentrate” World Stem Cell Summit. (2016) West Palm Beach, FL.
5 Barrientos, Stephan, et al. “Growth factors and cytokines in wound healing.” Wound Repair and Regeneration 16.5 (2008): 585-601.
6 Wang, Shaowei, et al. “Identification of α2‐Macroglobulin as a Master Inhibitor of Cartilage‐Degrading Factors That Attenuates the Progression of Posttraumatic Osteoarthritis.” Arthritis & rheumatology 66.7 (2014): 1843-1853
Additional information
| case-quantity | 10 |
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Related Products
ART BMC Plus
(SKU: 0886-2000)
The ART BMC PLUS system processes autologous bone marrow aspirate at the point of care. The recovers a high percentage of nucleated, progenitor and other cells by a selection of concentrate from a patented controlled collection system in the centrifuged stack. The integrated filter allows for the ultrafiltration of proteins from the platelet poor plasma.
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