ART BMC Plus

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Description

What is the ART BMC Plus?

  • The ART BMC Plus system processes autologous bone marrow concentrate effectively and efficiently at point-of-care.
  • The system recovers the greatest percentage of nucleated and progenitor cells
  •  The ART BMC Plus features integrated fibers for plasma concentration with minimal sterile breaks to create a fluid rich containing proteins such as VEGF, PDG-F, TGF-β, FGF, Alpha-2 Macroglobulin, Interleukin-1 receptor antagonist protein, and fibrinogen
  • Functionally closed system to minimize sterile breaks
  • Thumbwheel allows for selective deconstruction of fluid stack for personalized fluid products
  • Efficient concentration yields ultra-low hematocrit with only 1 spin
  • 15-20 minute processing time
  • Consistently achieves high yields of platelets and mononuclear cells
  • GFC = Growth Factor Concentrate = Concentrated Plasma
  • GFC Clot = Fibrin Glue with Proteins & Growth Factors!

Included:

  • (1) ART BMC Plus Disposable
  • (1) Clot Filter
  • (3) 35mL Syringes
  • (1) 30mL Vaclok
  • (2) F-F luer connectors
  • (2) syringe caps

Features

  • Fully integrated device to minimize sterile breaks
  • Disposable
  • Thumbwheel allows for variable processing volume
  • Only BMC device on the market with integrated fibers

Benefits

  • High progenitor cell recovery (avg 90 %)1
  • High platelet recovery (avg 71 %)1
  • Eliminates turbulence by keeping buffy coat in the collection zone
  • Ultrafiltration of plasma to obtain essential proteins & growth factors (3x total protein concentration)2

What Proteins, Growth Factors, and Molecules are Present in GFC?2

  • VEGF5
    • New blood vessel growth
    • Endothelial cell migration and proliferation
  • PDGF5
    • New blood vessel growth
    • MSC recruitment and proliferation
    • Helps form bone
    • Increases collagen synthesis
  • TGF-Beta5
    • MSC proliferation
    • Bone matrix deposition
  • FGF5
    • MSC proliferation
    • Wound healing
  • Alpha 2-Macroglobulin (A2M)6
    • Prevents cartilage degeneration
  • IRAP3
    • Interleukin-1 receptor antagonist protein
    • High levels in bone marrow
    • Decreases inflammation
  • FIBRINOGEN5
    • Critcal for clot formation
Cell Type Bone marrow concentrate and growth factor
Cell Source BMA
Cell Content / Recovery 90% progenitor cells (CD34+, CFU-F); 71% platelets1
Protein Concentrate Yes
FDA Status Class I – Exempt

1 Karli et al. Autologous Regenerative Therapies: Rapid Concentration of Progenitor Cells, Platelets, and Proteins at the Point-of-Care” TERMIS Annual Meeting. (2015) Boston, MA

2 Monteforte et al. “Autologous Protein Scaffold Isolated from Platelet Poor Plasma in Bone Marrow Concentrate” World Stem Cell Summit. (2016) West Palm Beach, FL.

3 Cassano, Jennifer M., et al. “Bone marrow concentrate and platelet-rich plasma differ in cell distribution and interleukin 1 receptor antagonist protein concentration.” Knee Surgery, Sports Traumatology, Arthroscopy (2016): 1-10.

4 Monteforte et al. “Autologous Protein Scaffold Isolated from Platelet Poor Plasma in Bone Marrow Concentrate” World Stem Cell Summit. (2016) West Palm Beach, FL.

5 Barrientos, Stephan, et al. “Growth factors and cytokines in wound healing.” Wound Repair and Regeneration 16.5 (2008): 585-601.

6 Wang, Shaowei, et al. “Identification of α2‐Macroglobulin as a Master Inhibitor of Cartilage‐Degrading Factors That Attenuates the Progression of Posttraumatic Osteoarthritis.” Arthritis & rheumatology 66.7 (2014): 1843-1853

Additional information

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case-quantity

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